Mib1^tm2Kong
Targeted Allele Detail

Summary

• Symbol: Mib1^tm2Kong
• Name: MIB E3 ubiquitin protein ligase 1; targeted mutation 1, Young-Yun Kong
• MGI ID: MGI:3804448
• Synonyms: Mib1^f
• Gene: Mib1 Location: Chr18:10725548-10818704 bp, + strand Genetic Position: Chr18, 5.35 cM
• Alliance: Mib1^tm2Kong page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130369
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination was used to remove the neo cassette leaving exons 2 and 3 floxed. (J:130369)

Expression

In Mice Carrying this Mutation:	48 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mib1 Mutation: 55 strains or lines available

References

• Original: J:130369 Koo BK, et al., An obligatory role of mind bomb-1 in notch signaling of Mammalian development. PLoS One. 2007;2(11):e1221
• All: 23 reference(s)