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Irs1tm1Mfw
Targeted Allele Detail
Nomenclature
Symbol: Irs1tm1Mfw
Name: insulin receptor substrate 1; targeted mutation 1, Morris F White
MGI ID: MGI:3803962
Synonyms: Irs1L
Gene: Irs1  Location: Chr1:82233101-82291416 bp, - strand  Genetic Position: Chr1, 42.0 cM, cytoband C5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137845
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of the 5' untranslated region and a floxed neo cassette was inserted downstream of the open reading frame. Transient cre expression in ES cells was used to remove the neo cassette. (J:137845)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irs1 Mutation:  2 strains or lines available
References
Original:  J:137845 Dong XC, et al., Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008 Jul;8(1):65-76
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory