Irs1^tm1Mfw
Targeted Allele Detail

Summary

• Symbol: Irs1^tm1Mfw
• Name: insulin receptor substrate 1; targeted mutation 1, Morris F White
• MGI ID: MGI:3803962
• Synonyms: Irs1^L
• Gene: Irs1 Location: Chr1:82210822-82269137 bp, - strand Genetic Position: Chr1, 42.0 cM, cytoband C5
• Alliance: Irs1^tm1Mfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137845
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the 5' untranslated region and a loxP site flanked neomycin resistance gene cassette was inserted downstream of the open reading frame. Transient cre expression in ES cells was used to remove the neo cassette. (J:137845)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs1 Mutation: 51 strains or lines available

References

• Original: J:137845 Dong XC, et al., Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008 Jul;8(1):65-76
• All: 22 reference(s)