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Laptm5tm1Jow
Targeted Allele Detail
Nomenclature
Symbol: Laptm5tm1Jow
Name: lysosomal-associated protein transmembrane 5; targeted mutation 1, Jiyang O-Wang
MGI ID: MGI:3803960
Gene: Laptm5  Location: Chr4:130913125-130936141 bp, + strand  Genetic Position: Chr4, 64.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137841
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1, that contains the transcription initiation codon, was replaced by a floxed neo cassette. The absence of protein product was confirmed by immunohistochemistry and western blot analysis. (J:137841)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Laptm5 Mutation:  20 strains or lines available
References
Original:  J:137841 Ouchida R, et al., A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation. Immunity. 2008 Jul;29(1):33-43
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory