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Targeted Allele Detail
Symbol: Fli1tm1.1Dkw
Name: Friend leukemia integration 1; targeted mutation 1.1, Dennis K Watson
MGI ID: MGI:3803949
Synonyms: Fli-1deltaCTA
Gene: Fli1  Location: Chr9:32422204-32542861 bp, - strand  Genetic Position: Chr9, 17.74 cM
Germline Transmission:  Earliest citation of germline transmission: J:137876
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted into exon 9 via homologous recombination resulting in a premature stop codon between the DNA-binding domain and the CTA domain. The neo cassette was removed by germ line, cre-mediated recombination. Removal of the C-terminal domain results in a 40% to 50% reduction in transcriptional activation activity and the production of a truncated protein. (J:137876)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fli1 Mutation:  15 strains or lines available
Original:  J:137876 Zhang XK, et al., The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. 2008 Aug 1;181(3):1644-54
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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