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Itgb4tm1.1Mfel
Targeted Allele Detail
Nomenclature
Symbol: Itgb4tm1.1Mfel
Name: integrin beta 4; targeted mutation 1.1, Maria Laura Feltri
MGI ID: MGI:3803794
Synonyms: beta4-
Gene: Itgb4  Location: Chr11:115974725-116008412 bp, + strand  Genetic Position: Chr11, 80.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137852
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre-mediated recombination was used to remove exon 2. The absence of protein expression was confirmed by immunohistochemistry on the dermal-epidermal layer. (J:137852)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb4 Mutation:  5 strains or lines available
References
Original:  J:137852 Nodari A, et al., Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci. 2008 Jun 25;28(26):6714-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory