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Tcf3tm1Mbu
Targeted Allele Detail
Nomenclature
Symbol: Tcf3tm1Mbu
Name: transcription factor 3; targeted mutation 1, Meinrad Busslinger
MGI ID: MGI:3803637
Synonyms: Tcfe2afl
Gene: Tcf3  Location: Chr10:80409514-80433647 bp, - strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137719
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 17 and an frt-flanked GFP-neo cassette with a 5' loxP site and 6 poly-adenylation sequences was inserted downstream of exon 19. (J:137719)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tcf3 Mutation:  12 strains or lines available
References
Original:  J:137719 Kwon K, et al., Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity. 2008 Jun;28(6):751-62
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory