Lasp1^tm1Chew
Targeted Allele Detail

Summary

• Symbol: Lasp1^tm1Chew
• Name: LIM and SH3 protein 1; targeted mutation 1, Catherine S Chew
• MGI ID: MGI:3802612
• Gene: Lasp1 Location: Chr11:97689826-97729590 bp, + strand Genetic Position: Chr11, 61.1 cM, cytoband C-D
• Alliance: Lasp1^tm1Chew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137526
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a floxed neo cassette. Transient cre expression in ES cells was used to remove the neo cassette. The absence of protein was confirmed by western blot analysis on gastric mucosae extracts. (J:137526)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lasp1 Mutation: 169 strains or lines available

References

• Original: J:137526 Chew CS, et al., Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion. Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G37-G44
• All: 3 reference(s)