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Targeted Allele Detail
Symbol: Cremtm1.1Endo
Name: cAMP responsive element modulator; targeted mutation 1.1, Shogo Endo
MGI ID: MGI:3802585
Gene: Crem  Location: Chr18:3266354-3337773 bp, - strand  Genetic Position: Chr18, 2.14 cM, cytoband A
Germline Transmission:  Earliest citation of germline transmission: J:137666
Parent Cell Line:  MS12 (ES Cell)
Strain of Origin:  C57BL/6NSlc
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon P2 and a neo cassette with a 3' loxP site was inserted downstream of exon P2. Transient cre expression in fertilized oocytes was used to remove the neo cassette and exon P2. (J:137666)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crem Mutation:  21 strains or lines available
Original:  J:137666 Kojima N, et al., Inducible cAMP early repressor acts as a negative regulator for kindling epileptogenesis and long-term fear memory. J Neurosci. 2008 Jun 18;28(25):6459-72
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory