Plskt93^SM/J
QTL Variant Detail

Summary

• QTL variant: Plskt93^SM/J
• Name: pleiotropic skeletal traits 93; SM/J
• MGI ID: MGI:3802565
• QTL: Plskt93 Location: unknown Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:134690

Linkage analysis was performed on 1040 (LG/J x SM/J)F2 animals to identify genetic loci associated with skeletal traits. The F2 population consists of two sets of intercrosses where intercross I (n=533) was phenotyped at 10-weeks of age and intercross II(n=507) was phenotyped between 72- and 237-days of age. Parental strain LG/J displays increased body weight compared to SM/J. Seventy skeletal traits were measured. Intercross I was genotyped for 76 microsatellite markers on 19 autosomes (excluding X chromosome). Intercross II was genotyped at 95 microsatellite markers and 369 SNP markers, including 16 SNPs on chromosome X. One hundred five pleiotropic loci were identified representing 798 single trait QTLs. The average number of traits associated per QTLwas 7.6. In general, LG/J-derived alleles confer increased skeletal trait measurements.

On mouse Chromosome X, three skeletal trait QTLs mapped to 16 cM (Tcdl; LPR=3.99), 25 cM (Plskt93; LPR=1.91) and 58 cM (Plskt94; LPR=2.44).

Linkage to skeletal measurement third caudal length mapped to 16 cM and is designated Tcdl (third caudal length). The QTL confidence interval spans 7 cM to 22 cM.

Plskt93 (pleiotropic skeletal traits 93) is associated with skeletal measurement first lumbar length at 25 cM on chromosome X. This locus also shows linkage to third lumbar length in females. The Plskt93 confidence interval spans 10 cM to 40 cM.

Plskt94 (pleiotropic skeletal traits 94) maps to 58 cM and is associated with three skeletal measurements- interorbital width, cranial vault widthand body weight at 10 weeks of age. The Plskt94 QTL interval spans 57 cM to 61 cM.

References

• Original: J:134690 Kenney-Hunt JP, et al., Pleiotropic patterns of quantitative trait Loci for 70 murine skeletal traits. Genetics. 2008 Apr;178(4):2275-88
• All: 1 reference(s)