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Wt1tm2(cre/ERT2)Wtp
Targeted Allele Detail
Nomenclature
Symbol: Wt1tm2(cre/ERT2)Wtp
Name: WT1 transcription factor; targeted mutation 2, William T Pu
MGI ID: MGI:3801682
Synonyms: Wt1CreERT2, Wt1iCre, Wt1tm2(cre/ESR1)Wtp
Gene: Wt1  Location: Chr2:104956874-105003959 bp, + strand  Genetic Position: Chr2, 55.06 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137426
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with an inducible cre ESR1 (ERT2) fusion followed by an frt-flanked neo cassette. Germ line, flp-mediated recombination was used to remove the neo cassette. (J:137426)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Wt1     Summary of all recombinase alleles driven by Wt1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wt1 Mutation:  28 strains or lines available
References
Original:  J:137426 Zhou B, et al., Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 3;454(7200):109-13
All:  72 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory