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Targeted Allele Detail
Symbol: Ifih1tm1Aki
Name: interferon induced with helicase C domain 1; targeted mutation 1, Shizuro Akira
MGI ID: MGI:3801032
Synonyms: MDA5-
Gene: Ifih1  Location: Chr2:62595798-62646255 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:137522
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 and 3 containing the DExD/H box were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:137522)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ifih1 Mutation:  20 strains or lines available
Original:  J:137522 Kato H, et al., Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006 May 4;441(7089):101-5
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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