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Targeted Allele Detail
Symbol: Fmn1tm1Awb
Name: formin 1; targeted mutation 1, Anthony Wynshaw-Boris
MGI ID: MGI:3800994
Synonyms: ldGKO
Gene: Fmn1  Location: Chr2:113327736-113716767 bp, + strand  Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
Germline Transmission:  Earliest citation of germline transmission: J:43337
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA pgk-neo cassette was inserted 195 bp 3' of the start codon of the 5'-terminal exon of isoform IV (exon 6) and stop codons were introduced in all 3 reading frames. Immunoblot analysis failed to detect isoform IV in adult kidney and E10.5 whole body lysates. (J:43337)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmn1 Mutation:  6 strains or lines available
Original:  J:43337 Wynshaw-Boris A, et al., The role of a single formin isoform in the limb and renal phenotypes of limb deformity. Mol Med. 1997 Jun;3(6):372-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory