Tg(Prnp-Abca1)EHol
Transgene Detail

Summary

• Symbol: Tg(Prnp-Abca1)EHol
• Name: transgene insertion E, David M Holtzman
• MGI ID: MGI:3800823
• Synonyms: PrP-mAbca1 line E
• Transgene: Tg(Prnp-Abca1)EHol Location: unknown
• Alliance: Tg(Prnp-Abca1)EHol page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-Abca1)EHol expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Abca1 (MGI:99607)

• Mutation details: A transgenic construct containing the mouse Abca1 (ATP-binding cassette, sub-family A (ABC1), member 1) gene under the control of the mouse Prnp (prion protein) promoter was injected into fertilized B6CBAF1 eggs. Founder line E was subsequently established. These founder line E mice have a 6-fold increase in expression of ABCA1 in the cortex over wildtype levels. Transgene expression is high in total brain tissue, kidney, testis and muscle as detected by Western blot analysis. (J:131400)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:131400 Wahrle SE, et al., Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest. 2008 Feb;118(2):671-82
• All: 2 reference(s)