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Targeted Allele Detail
Symbol: Waptm2(rtTA)Kuw
Name: whey acidic protein; targeted mutation 2, Kay Uwe Wagner
MGI ID: MGI:3799057
Gene: Wap  Location: Chr11:6585482-6588637 bp, - strand  Genetic Position: Chr11, 4.61 cM
Germline Transmission:  Earliest citation of germline transmission: J:148684
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Transactivator)
Mutation:    Insertion
Mutation detailsThe coding sequence for rtTA was inserted into the 5'-UTR along with a floxed neomycin selection cassette. The neo selection cassette was eliminated in founder line 7A3 by crossing properly targeted mice to Tg(MMTV-cre)1Mam transgenic animals. When mice were given doxycycline, transgene expression was restricted to mammary epithelial cells as determined by crosses with two different rtTA reporter strains. (J:148684)
Generation of the Waptm2(rtTA)Kuw allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wap Mutation:  31 strains or lines available
Original:  J:148684 Creamer BA, et al., Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging. Genesis. 2009 Apr;47(4):234-45
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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