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Gli3tm1Alj
Targeted Allele Detail
Nomenclature
Symbol: Gli3tm1Alj
Name: GLI-Kruppel family member GLI3; targeted mutation 1, Alexandra L Joyner
MGI ID: MGI:3798847
Synonyms: Gli3F, Gli3flox
Gene: Gli3  Location: Chr13:15463723-15730026 bp, + strand  Genetic Position: Chr13, 5.43 cM, cytoband A2
Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137136
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 8 and an additional loxP site was inserted downstream of exon 8. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 8 floxed. (J:137136)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gli3 Mutation:  10 strains or lines available
References
Original:  J:137136 Blaess S, et al., Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development. 2008 Jun;135(12):2093-103
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory