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Targeted Allele Detail
Symbol: Mta2tm1.1Yzha
Name: metastasis-associated gene family, member 2; targeted mutation 1.1, Yi Zhang
MGI ID: MGI:3798815
Synonyms: Mta21lox, Mta2delta
Gene: Mta2  Location: Chr19:8941875-8952303 bp, + strand  Genetic Position: Chr19, 6.04 cM, cytoband B
Adult Mta2tm1.1Yzha/Mta2tm1.1Yzha mice exhibit autoimmunity-related phenotypes in multiple organs

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:137101
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsGerm line, cre-mediated recombination was used to remove the neo cassette and exons 4 through 11. The absence of protein product was confirmed by western blot analysis on liver extracts. (J:137101)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mta2 Mutation:  12 strains or lines available
Original:  J:137101 Lu X, et al., Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice. J Biol Chem. 2008 May 16;283(20):13825-33
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory