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Del(5Letm1-D5Mit81)3Jcs
Radiation induced Allele Detail
Nomenclature
Symbol: Del(5Letm1-D5Mit81)3Jcs
Name: deletion, Chr 5, John C. Schimenti 3; deletion, Chr 5, John C Schimenti 3
MGI ID: MGI:3798084
Synonyms: Del3Jcs, Hdhdf6J
Gene: Del(5LetM1-D5Mit81)3Jcs  Location: Chr5:33739673-50331534 bp  Genetic Position: Chr5, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67077
Parent Cell Line:  v6.4 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S4/SvJae)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Intergenic deletion
  Del(5Letm1-D5Mit81)3Jcs involves 197 genes/genome features (Gm5107, Gm19841, Gm3364 ...) View all
 
Mutation detailsTargeted insertion of thymidine kinase into the C57BL/6J derived Chromosome 5 Htt locus in the v6.4 ES cell line was followed by 400 Gy of gamma radiation, FIAU selection, and injection into C57BL/6J blastocysts. The deletion includes the full Wolf-Hirschhorn syndrome critical region and extends to include D5Mit81. (J:67077)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(5LetM1-D5Mit81)3Jcs Mutation:  0 strains or lines available
References
Original:  J:67077 Naf D, et al., Mouse models for the Wolf-Hirschhorn deletion syndrome. Hum Mol Genet. 2001 Jan 15;10(2):91-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory