Del(5D5Mit148-Qdpr)2Jcs
Chemically induced Allele Detail

Summary

• Symbol: Del(5D5Mit148-Qdpr)2Jcs
• Name: deletion, Chr 5, John C. Schimenti 2; deletion, Chr 5, John C Schimenti 2
• MGI ID: MGI:3798083
• Synonyms: Del2Jcs, Hdh^df2J
• Gene: Del(5D5Mit148-Qdpr)2Jcs Location: Chr5:32133234-45607571 bp Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67077
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(5D5Mit148-Qdpr)2Jcs involves 201 genes/genome features (Gm10205, Gm15865, Gm20671 ...) View all
• Mutation details: Targeted insertion of thymidine kinase into the C57BL/6J derived Chromosome 5 Htt locus in the v6.4 ES cell line was followed by 400 Gy of gamma radiation, FIAU selection, and injection into C57BL/7J blastocysts. The deletion includes the full Wolf-Hirschhorn syndrome critical region and extends to include D5Mit148 and Qdpr. (J:67077)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(5D5Mit148-Qdpr)2Jcs Mutation: 0 strains or lines available

References

• Original: J:67077 Naf D, et al., Mouse models for the Wolf-Hirschhorn deletion syndrome. Hum Mol Genet. 2001 Jan 15;10(2):91-8
• All: 1 reference(s)