About   Help   FAQ
Nrxn2tm2Sud
Targeted Allele Detail
Summary
Symbol: Nrxn2tm2Sud
Name: neurexin II; targeted mutation 2, Thomas C Sudhof
MGI ID: MGI:3797418
Synonyms: Nrxn2beta cKO
Gene: Nrxn2  Location: Chr19:6468786-6583247 bp, + strand  Genetic Position: Chr19, 4.65 cM
Alliance: Nrxn2tm2Sud page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:224592
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into the 5' end of a modified exon 17, which contains an hemagglutinin (HA) reporter tag followed by a FRT-flanked neomycin resistance cassette and a loxP site. Flp-mediated recombination removed the selection cassette and left the modified exon 17 floxed. The HA insert does not affect the expression of neurexin 2 gene, but it is very difficult to detect GFP signals in the tissue by immunohistochemistry. (J:224592)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrxn2 Mutation:  87 strains or lines available
References
Original:  J:224592 Anderson GR, et al., beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell. 2015 Jul 30;162(3):593-606
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory