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Nrxn1tm2Sud
Targeted Allele Detail
Nomenclature
Symbol: Nrxn1tm2Sud
Name: neurexin I; targeted mutation 2, Thomas C Sudhof
MGI ID: MGI:3797417
Synonyms: Nrxn1beta cKO
Gene: Nrxn1  Location: Chr17:90033631-91093071 bp, - strand  Genetic Position: Chr17, 59.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:224592
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into the 5' end of a modified exon 18, which contains an EGFP reporter gene followed by FRT-flanked neomycin resistance cassette and a loxP site. Flp-mediated recombination removed the selection cassette and left the modified exon 18 floxed. The GFP insert does not affect the expression of neurexin 1 gene, but it is very difficult to detect GFP signals in the tissue by immunohistochemistry or direct fluorescence. (J:224592)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrxn1 Mutation:  15 strains or lines available
References
Original:  J:224592 Anderson GR, et al., beta-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell. 2015 Jul 30;162(3):593-606
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory