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Targeted Allele Detail
Symbol: Ccl25tm1.1Mal
Name: chemokine (C-C motif) ligand 25; targeted mutation 1.1, Bernard Malissen
MGI ID: MGI:3797365
Synonyms: Ccl25tm1Mal
Gene: Ccl25  Location: Chr8:4375210-4410020 bp, + strand  Genetic Position: Chr8, 2.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:136944
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 2 (including the translation initiation site) and all of exons 3 and 4 were replaced with a floxed neomycin resistance gene cassette. The neo cassette was removed through subsequent germline, cre-mediated recombination. (J:136944)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccl25 Mutation:  38 strains or lines available
Original:  J:136944 Wurbel MA, et al., Impaired accumulation of antigen-specific CD8 lymphocytes in chemokine CCL25-deficient intestinal epithelium and lamina propria. J Immunol. 2007 Jun 15;178(12):7598-606
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory