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Chemically induced Allele Detail
Symbol: Foxc1hith
Name: forkhead box C1; hole-in-the-head
MGI ID: MGI:3797008
Synonyms: Foxc1line351, m351Asp
Gene: Foxc1  Location: Chr13:31806691-31810643 bp, + strand  Genetic Position: Chr13, 13.52 cM
Eye, skull, and brain abnormalities in Foxc1hith/Foxc1hith mice

Show the 2 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsENU mutatgenesis induced a T to C transition resulting in an amino acid substitution of leucine for proline at position 107 (P107L). This mutation occurs in the DNA binding forkhead domain. (J:136459)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxc1 Mutation:  9 strains or lines available
Original:  J:136795 Zarbalis K, et al., A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2004 Aug;2(8):E219
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory