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Foxc1hith
Chemically induced Allele Detail
Summary
Symbol: Foxc1hith
Name: forkhead box C1; hole-in-the-head
MGI ID: MGI:3797008
Synonyms: Foxc1line351, m351Asp
Gene: Foxc1  Location: Chr13:31990629-31994618 bp, + strand  Genetic Position: Chr13, 13.52 cM
Alliance: Foxc1hith page
Eye, skull, and brain abnormalities in Foxc1hith/Foxc1hith mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutatgenesis induced a T to C transition resulting in an amino acid substitution of phenylalanine with leucine at position 107 (F107L). This mutation occurs in the DNA binding forkhead domain. (J:136459)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxc1 Mutation:  29 strains or lines available
References
Original:  J:136795 Zarbalis K, et al., A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2004 Aug;2(8):E219
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory