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C1qatm1.1Tenn
Targeted Allele Detail
Nomenclature
Symbol: C1qatm1.1Tenn
Name: complement component 1, q subcomponent, alpha polypeptide; targeted mutation 1.1, Andrea J Tenner
MGI ID: MGI:3796996
Gene: C1qa  Location: Chr4:136623228-136626114 bp, - strand  Genetic Position: Chr4, 69.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136269
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsFour amino acids within the exon 1 of the mouse sequence were converted to the corresponding human sequence and introduced by targeted homologous recombination with loxP flanked neo cassette place in intron 1. The neo cassette was removed either by crossing with deleter cre expressing strain or by transient transfection with cre. (J:136269)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any C1qa Mutation:  14 strains or lines available
References
Original:  J:136269 Li M, et al., Development of a humanized C1q A chain knock-in mouse: Assessment of antibody independent ss-amyloid induced complement activation. Mol Immunol. 2008 Jun;45(11):3244-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory