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Arid1atm1.2Zhwa
Targeted Allele Detail
Nomenclature
Symbol: Arid1atm1.2Zhwa
Name: AT rich interactive domain 1A (SWI-like); targeted mutation 1.2, Zhong Wang
MGI ID: MGI:3796520
Synonyms: BAF250a-
Gene: Arid1a  Location: Chr4:133679008-133756769 bp, - strand  Genetic Position: Chr4, 66.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134633
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsAn frt-flanked betageo cassette with a 3' loxP site and a 5' SV40-polyA tail was inserted downstream of exon 8 and an additional loxP site was inserted upstream of exon 8. Transient flp expression in ES cells was used to remove the betageo cassette and leave exon 8 floxed. Cre expression in germline cells removed exon 8 and created a null allele. No gene product was detected by PCR in homozygous null embryos. (J:134633)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arid1a Mutation:  146 strains or lines available
References
Original:  J:134633 Gao X, et al., ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6656-61
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory