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Irak2tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Irak2tm1Aki
Name: interleukin-1 receptor-associated kinase 2; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3796171
Gene: Irak2  Location: Chr6:113638467-113695026 bp, + strand  Genetic Position: Chr6, 52.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136290
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 4 through exon 6 was replaced with a floxed neo cassette. The absence of protein product was confirmed by western blot analysis on macrophage extracts. (J:136290)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irak2 Mutation:  41 strains or lines available
References
Original:  J:136290 Kawagoe T, et al., Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat Immunol. 2008 Jun;9(6):684-91
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory