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Targeted Allele Detail
Symbol: Il17ftm1Cdon
Name: interleukin 17F; targeted mutation 1, Chen Dong
MGI ID: MGI:3796155
Synonyms: Il17-, IL-17F-RFP, Il17rfp
Gene: Il17f  Location: Chr1:20777146-20785274 bp, - strand  Genetic Position: Chr1, 6.49 cM
Germline Transmission:  Earliest citation of germline transmission: J:136279
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsAn frt-flanked puromycin resistance cassette followed by an IRES RFP cassette was inserted into exon 2. Germ line, flp-mediated recombination was used to remove the puro cassette. The absence of protein expression was confirmed by enzyme-linked immunosorbent assay on splenocytes. This is a null allele and a reporter allele. (J:136279)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17f Mutation:  19 strains or lines available
Original:  J:136279 Yang XO, et al., Regulation of inflammatory responses by IL-17F. J Exp Med. 2008 May 12;205(5):1063-75
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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