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Ackr3tm1Jgo
Targeted Allele Detail
Nomenclature
Symbol: Ackr3tm1Jgo
Name: atypical chemokine receptor 3; targeted mutation 1, Jan A Gossen
MGI ID: MGI:3796065
Gene: Ackr3  Location: Chr1:90203980-90215724 bp, + strand  Genetic Position: Chr1, 45.28 cM
Enlarged hearts with cardiomyocyte hyperplasia, degeneration and fibrosis in some Ackr3tm1Jgo/Ackr3tm1Jgo mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136246
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 containing the translation initiation codon was replaced with a lacZ/neo cassette. The absence of transcript was confirmed by RT-PCR on heart extracts. Reporter gene expression was detected in cardiomyocytes, vascular endothelial cells of the lung and heart, the cerebral cortex and in the osteocytes of the bone. (J:136246)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ackr3 Mutation:  13 strains or lines available
References
Original:  J:136246 Gerrits H, et al., Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. Genesis. 2008 May;46(5):235-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory