Tg(Myh6-Des*)641Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Des*)641Rbns
• Name: transgene insertion 641, Jeffrey Robbins
• MGI ID: MGI:3795721
• Synonyms: D7-des
• Transgene: Tg(Myh6-Des*)641Rbns Location: unknown
• Alliance: Tg(Myh6-Des*)641Rbns page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Des*)641Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Des (MGI:94885)

• Mutation details: The alpha-myosin heavy chain promoter drives cardiac-specific expression of mouse desmin containing a deletion of seven amino acids (R173 through E179). Transgene copy number is 15 in this line. Transgenic line 83 was also generated. (J:108730)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:108730 Wang X, et al., Mouse model of desmin-related cardiomyopathy. Circulation. 2001 May 15;103(19):2402-7
• All: 9 reference(s)