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Sox8tm1Mkob
Targeted Allele Detail
Nomenclature
Symbol: Sox8tm1Mkob
Name: SRY (sex determining region Y)-box 8; targeted mutation 1, Moira K O'Bryan
MGI ID: MGI:3795214
Gene: Sox8  Location: Chr17:25565893-25570686 bp, - strand  Genetic Position: Chr17, 12.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136098
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 through 2 was replaced with a lacZ gene and floxed neo cassette. The neo cassette was removed by germ line, cre-mediated recombination. The absence of protein product was confirmed by western blot analysis on testis extracts. This is a null allele and a reporter allele. (J:136098)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox8 Mutation:  14 strains or lines available
References
Original:  J:136098 O'Bryan MK, et al., Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Dev Biol. 2008 Apr 15;316(2):359-70
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory