Nkx6-3^tm1Shiv
Targeted Allele Detail

Summary

• Symbol: Nkx6-3^tm1Shiv
• Name: NK6 homeobox 3; targeted mutation 1, Ramesh Shivdasani
• MGI ID: MGI:3795186
• Gene: Nkx6-3 Location: Chr8:23643287-23648964 bp, + strand Genetic Position: Chr8, 11.42 cM, cytoband A3
• Alliance: Nkx6-3^tm1Shiv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136085
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neo cassette. The absence of transcript was confirmed by qRT-PCR analysis on stomach extracts. (J:136085)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx6-3 Mutation: 19 strains or lines available

References

• Original: J:136085 Choi MY, et al., Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Mol Cell Biol. 2008 May;28(10):3208-18
• All: 2 reference(s)