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Nkx6-3tm1Shiv
Targeted Allele Detail
Nomenclature
Symbol: Nkx6-3tm1Shiv
Name: NK6 homeobox 3; targeted mutation 1, Ramesh Shivdasani
MGI ID: MGI:3795186
Gene: Nkx6-3  Location: Chr8:23153269-23158948 bp, + strand  Genetic Position: Chr8, 11.42 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136085
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced with a neo cassette. The absence of transcript was confirmed by qRT-PCR analysis on stomach extracts. (J:136085)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 25 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx6-3 Mutation:  7 strains or lines available
References
Original:  J:136085 Choi MY, et al., Requirement of the tissue-restricted homeodomain transcription factor Nkx6.3 in differentiation of gastrin-producing G cells in the stomach antrum. Mol Cell Biol. 2008 May;28(10):3208-18
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory