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Atxn2tm1.1Geno
Targeted Allele Detail
Nomenclature
Symbol: Atxn2tm1.1Geno
Name: ataxin 2; targeted mutation 1.1, Genoway
MGI ID: MGI:3793867
Synonyms: Atxn2tm1.1Aub, Sca2-
Gene: Atxn2  Location: Chr5:121711609-121814950 bp, + strand  Genetic Position: Chr5, 61.93 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135320
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient cre expression in ES cells ws used to remove exon 1 and the neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. (J:135320)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atxn2 Mutation:  19 strains or lines available
References
Original:  J:135320 Lastres-Becker I, et al., Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice. Hum Mol Genet. 2008 May 15;17(10):1465-81
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory