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Tg(Myl1-Igf1)1Nros
Transgene Detail
Nomenclature
Symbol: Tg(Myl1-Igf1)1Nros
Name: transgene insertion 1, Nadia Rosenthal
MGI ID: MGI:3793794
Synonyms: mIGF-1, MLC/mIgf-1
Transgene: Tg(Myl1-Igf1)1Nros  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene construct consists of a rat mIgf-1 cDNA driven by skeletal muscle-specific regulatory elements from the rat myosin light chain (MLC)-1/3 locus. Expression of the MLC/mIgf-1 transgene in adult mice was restricted to skeletal muscle and predominated in muscles enriched in fast fibers, such as the triceps or gastrocnemius. Transgene expression was reduced in slow muscles such as the soleus, where the MLC regulatory cassette is characteristically expressed at very low levels. (J:96432)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:96432 Musaro A, et al., Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nat Genet. 2001 Feb;27(2):195-200
All:  16 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory