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Transgene Detail
Symbol: Tg(Myl1-Igf1)1Nros
Name: transgene insertion 1, Nadia Rosenthal
MGI ID: MGI:3793794
Synonyms: mIGF-1, MLC/mIgf-1
Transgene: Tg(Myl1-Igf1)1Nros  Location: unknown  
Strain of Origin:  FVB
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Myl1-Igf1)1Nros expresses 1 gene
Mutation detailsThe transgene construct consists of a rat mIgf-1 cDNA driven by skeletal muscle-specific regulatory elements from the rat myosin light chain (MLC)-1/3 locus. Expression of the MLC/mIgf-1 transgene in adult mice was restricted to skeletal muscle and predominated in muscles enriched in fast fibers, such as the triceps or gastrocnemius. Transgene expression was reduced in slow muscles such as the soleus, where the MLC regulatory cassette is characteristically expressed at very low levels. (J:96432)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:96432 Musaro A, et al., Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nat Genet. 2001 Feb;27(2):195-200
All:  17 reference(s)

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MGI 6.01
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