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Pkd1tm2.1Som
Targeted Allele Detail
Summary
Symbol: Pkd1tm2.1Som
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 2.1, Stefan Somlo
MGI ID: MGI:3793792
Synonyms: Pkd1del2-4
Gene: Pkd1  Location: Chr17:24768808-24815482 bp, + strand  Genetic Position: Chr17, 12.4 cM
Alliance: Pkd1tm2.1Som page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135301
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    Germ line, cre-mediated recombination was used to remove exons 2 through 4. (J:135301)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkd1 Mutation:  153 strains or lines available
References
Original:  J:135301 Shibazaki S, et al., Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. Hum Mol Genet. 2008 Jun 1;17(11):1505-16
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory