Gt(ROSA)26Sortm1(RARA*)Soc
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(RARA*)Soc |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Shanthini Sockanathan |
MGI ID: |
MGI:3793772 |
Synonyms: |
dnRAR-alpha, R26RAR403, Rara403 conditional |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(RARA*)Soc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:135403
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, Dominant negative, Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(RARA*)Soc expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
RARA (5914) |
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Mutation details: A floxed neo-STOP cassette followed by a dominant negative form of human RARA (RAR403) was inserted into the ROSA locus. Cre mediated removal of the neo-STOP cassette is necessary for expression of RAR403.
(J:135403)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:135403 Rajaii F, et al., Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival, and cell fate specification. Dev Biol. 2008 Apr 15;316(2):371-82 |
All: |
17 reference(s) |
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