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Tg(Myh6*)1Lnwd
Transgene Detail
Nomenclature
Symbol: Tg(Myh6*)1Lnwd
Name: transgene insertion 1, Leslie Leinwand
MGI ID: MGI:3793766
Synonyms: deltaLCBDmyc
Transgene: Tg(Myh6*)1Lnwd  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x FVB/N)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6*)1Lnwd expresses 1 gene
 
Mutation detailsNucleotides 2,381 to 2,563 were deleted from published rat alpha-cardiac MHC and then fused to a COOH-terminal myc-tagged MHC fragment. This mutant cDNA was expressed under the control of a 3.3 kb of rat a-cardiac MHC promoter and the cDNA was followed by the mouse beta-globin terminator. The encoded protein lacks the light chain binding domain. (J:55938)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:55938 Welikson RE, et al., Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice. Am J Physiol. 1999 Jun;276(6 Pt 2):H2148-58
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory