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Tg(H2-Aa)26Dim
Transgene Detail
Nomenclature
Symbol: Tg(H2-Aa)26Dim
Name: transgene insertion 26, Diane Mathis
MGI ID: MGI:3793688
Synonyms: Aa26
Transgene: Tg(H2-Aa)26Dim  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(H2-Aa)26Dim expresses 1 gene
 
Mutation detailsA transgenic construct containing the entire mouse (AKR/J strain) H2-Aa kappa genomic DNA sequence was microinjected into (C57BL/6 x SJL)F2 embryos. Two lines Aalpha10 and Aalpha26 were generated. Line 26 was crossed to mice carrying Tg(H2-Ab1)62Dim and the resulting double transgenic line was donated to The Jackson Laboratory. The construct was also injected into C57BL/6 embryos to have the transgene on a homogeneous genetic background. Line 46 was established (Aalpha46). S1-mapping shows normal patterns of high expression in spleen, lung and thymus. (J:110897)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:110897 Fehling HJ, et al., Functional consequences of overexpressed Ia antigens in AK alpha/AK beta transgenic mice. J Immunol. 1990 Apr 15;144(8):2865-74
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory