About   Help   FAQ
Tg(H2-Ea*deltaX)16Dim
Transgene Detail
Nomenclature
Symbol: Tg(H2-Ea*deltaX)16Dim
Name: transgene insertion 16, Diane Mathis
MGI ID: MGI:3793642
Synonyms: Tg(dX21,16)3Strasbourg, WEdeltaX21, WEdeltaX21-16
Transgene: Tg(H2-Ea*deltaX)16Dim  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(H2-Ea*deltaX)16Dim expresses 1 gene
 
Mutation detailsA 9 kb fragment of the H2-Ea(k) from the A/J mouse (clone lambdaA/J p34.13) was modified at 3 positions creating the WE32 construct (modified H2-Ea). This was used as the basis for a mutant H2-Ea gene having a deletion of the X box (from position -93 to -80). The resulting 8.2 kb transgenic construct WEdeltaX21 was injected into (C57BL/6 x SJL)F2 embryo pronuclei. Multiple lines - 5. 16, 23, and 24, were derived, and 16 was donated to The Jackson Laboratory. S1 nuclease mapping shows that H2-Ea mRNA is expressed in the spleen but initiation of most transcripts is aberrant, occurring at scattered positions throughout the 5' end. (J:135138)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:135138 Dorn A, et al., Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6249-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/16/2021
MGI 6.17
The Jackson Laboratory