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Targeted Allele Detail
Symbol: Gata6tm3.1Sad
Name: GATA binding protein 6; targeted mutation 3.1, Stephen A Duncan
MGI ID: MGI:3793425
Synonyms: Gata4-Gata6-
Gene: Gata6  Location: Chr18:11052510-11085636 bp, + strand  Genetic Position: Chr18, 5.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:135185
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 and 4 were floxed and cre-mediated recombination was used to remove the exons as well as the selection cassette. Gene targeting was performed ES cells that were homozygous for Gata4tm1.2Sad. The absence of Gata 4 and 6 transcripts was confirmed by RT-PCR on embryoid body extracts. (J:135185)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 23 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata6 Mutation:  9 strains or lines available
Original:  J:135185 Zhao R, et al., Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol. 2008 May 15;317(2):614-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory