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Adgre1m1Btlr
Chemically induced Allele Detail
Nomenclature
Symbol: Adgre1m1Btlr
Name: adhesion G protein-coupled receptor E1; mutation 1, Bruce Beutler
MGI ID: MGI:3793322
Synonyms: F4/80
Gene: Adgre1  Location: Chr17:57358686-57483529 bp, + strand  Genetic Position: Chr17, 29.8 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis mutation, which was discovered in an ENU mutagenesis screen for defective macrophage function, corresponds to an A-to-G transition at nucleotide position 1776 of the gene, in the 14th of 22 exons, that results in replacement of tyrosine by cysteine at amino acid position 579 of the protein. Macrophages from thioglycolate-elicited peritoneal exudates of homozygous mutant mice exhibit greatly reduced surface expression of the EMR1 (F4/80) protein, and heterozygous macrophages exhibit surface EMR1 expression intermediate between that of wild-type and homozygous cells. (J:135219)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adgre1 Mutation:  45 strains or lines available
References
Original:  J:135219 Zhou Z, et al., Reduced macrophage surface expression of F4/80 does not affect resistance to mouse cytomegalovirus (MCMV) or Listeria monocytogenes infection. MGI Direct Data Submission. 2008;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory