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Csnk1etm1.1Asil
Targeted Allele Detail
Nomenclature
Symbol: Csnk1etm1.1Asil
Name: casein kinase 1, epsilon; targeted mutation 1.1, Andrew S I Loudon
MGI ID: MGI:3793321
Synonyms: CK1epsilon-
Gene: Csnk1e  Location: Chr15:79417856-79443919 bp, - strand  Genetic Position: Chr15, 37.71 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135186
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsGerm line, cre-mediated recombination was used to remove exon 4 causing a frame shift and premature stop codon. The absence of protein product was confirmed by western blot analysis on brain extracts. (J:135186)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Csnk1e Mutation:  22 strains or lines available
References
Original:  J:135186 Meng QJ, et al., Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. Neuron. 2008 Apr 10;58(1):78-88
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory