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Csnk1etm1Asil
Targeted Allele Detail
Summary
Symbol: Csnk1etm1Asil
Name: casein kinase 1, epsilon; targeted mutation 1, Andrew S I Loudon
MGI ID: MGI:3793318
Synonyms: CK1epsilontau
Gene: Csnk1e  Location: Chr15:79302056-79339767 bp, - strand  Genetic Position: Chr15, 37.71 cM, cytoband E1
Alliance: Csnk1etm1Asil page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:135186
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Single point mutation
 
Mutation detailsA floxed neo cassette was inserted downstream of a modified exon 4 containing a C to T transition at base pair 12555 (C12555T) and an additional loxP site was inserted upstream of the modified exon 4. The neo cassette was removed by germ line, cre-mediated recombination that left the modified exon 4 floxed. The transition mimics a gain of function mutation identified in hamsters as having a destabilizing effect on Per1. (J:135186)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Csnk1e Mutation:  31 strains or lines available
References
Original:  J:135186 Meng QJ, et al., Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. Neuron. 2008 Apr 10;58(1):78-88
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory