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Nat1Rgsc1523
Chemically induced Allele Detail
Nomenclature
Symbol: Nat1Rgsc1523
Name: N-acetyl transferase 1; RIKEN Genomic Sciences Center (GSC), 1523
MGI ID: MGI:3793317
Synonyms: Nat1I95T
Gene: Nat1  Location: Chr8:67490968-67492531 bp, + strand  Genetic Position: Chr8, 33.38 cM, cytoband B3.1
Mutation
origin
Strain of Origin:  C57BL/6
Project Collection: RIKEN GSC ENU Project
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis generated a C to T transition that results in an amino acid substitution of threonine for isoleucine at position 95 (I95T). This mutation results in a 90% decrease in enzymatic activity. (J:134504)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nat1 Mutation:  10 strains or lines available
References
Original:  J:134504 Erickson RP, et al., An N-ethyl-N-nitrosourea-induced mutation in N-acetyltransferase 1 in mice. Biochem Biophys Res Commun. 2008 May 30;370(2):285-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory