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Mirc1tm1.2Tyj
Targeted Allele Detail
Nomenclature
Symbol: Mirc1tm1.2Tyj
Name: microRNA cluster 1, including Mir17 through Mir92-1; targeted mutation 1.2, Tyler Jacks
MGI ID: MGI:3790968
Synonyms: miR-17~92delta, Mirn17-92tm1.2Tyj
Gene: Mirc1  Location: Chr14:115043671-115044506 bp  Genetic Position: Chr14, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134861
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intergenic deletion
 
Mutation detailsCrossing Mirc1tm1.1Tyj mice to a Cre deleter strain (human ACTB beta actin promoter) excised the floxed cluster, including Mir17, Mir18a, Mir19a, Mir20a, Mir19b-1, and Mir92-1. This results in a null allele. (J:134861)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mirc1 Mutation:  6 strains or lines available
References
Original:  J:134861 Ventura A, et al., Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008 Mar 7;132(5):875-86
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory