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Nr1i2tm3Arte
Targeted Allele Detail
Nomenclature
Symbol: Nr1i2tm3Arte
Name: nuclear receptor subfamily 1, group I, member 2; targeted mutation 3, TaconicArtemis
MGI ID: MGI:3790846
Gene: Nr1i2  Location: Chr16:38248323-38294824 bp, - strand  Genetic Position: Chr16, 26.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140975
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll of the human sequence in Nr1i2tm1(NR1I2)Arte was deleted by germ line, phiC31 mediated recombination. Mouse exon 1 and exons 3-9 are still present along with an inserted splice acceptor polyA motif. Exon 1 is spliced to the polyA motif which terminates translation. (J:140975)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nr1i2 Mutation:  19 strains or lines available
References
Original:  J:140975 Scheer N, et al., A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Invest. 2008 Sep;118(9):3228-39
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory