Nr1i2^tm3Arte
Targeted Allele Detail

Summary

• Symbol: Nr1i2^tm3Arte
• Name: nuclear receptor subfamily 1, group I, member 2; targeted mutation 3, TaconicArtemis
• MGI ID: MGI:3790846
• Gene: Nr1i2 Location: Chr16:38068711-38115211 bp, - strand Genetic Position: Chr16, 26.64 cM
• Alliance: Nr1i2^tm3Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140975
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All of the human sequence in Nr1i2^{tm1(NR1I2)Arte} was deleted by germ line, phiC31 mediated recombination. Mouse exon 1 and exons 3-9 are still present along with an inserted splice acceptor polyA motif. Exon 1 is spliced to the polyA motif which terminates translation. (J:140975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Nr1i2 Mutation: 33 strains or lines available

References

• Original: J:140975 Scheer N, et al., A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Invest. 2008 Sep;118(9):3228-39
• All: 6 reference(s)