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Hbatm1(HBA)Tow
Targeted Allele Detail
Nomenclature
Symbol: Hbatm1(HBA)Tow
Name: hemoglobin alpha chain complex; targeted mutation 1, Timothy Townes
MGI ID: MGI:3790755
Synonyms: HbA, Hbahalpha
Gene: Hba  Location: unknown  Genetic Position: Chr11, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134980
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Deletion, Insertion
    The complex was replaced with human HBA. Details will be described elsewhere. (J:134980)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hba Mutation:  8 strains or lines available
Notes
Mice homozygous for this allele and for Hbbtm2(HBG1,HBD,HBB*)Ryan allele Show Phenotypic Similarity to Human Syndrome: Beta Thalassemia Major and Cooley Anemia (J:148521)
Mice homozygous for this allele and compound heterozygote for Hbbtm2(HBG1,HBD,HBB*)Ryan and Hbbtm3(HBG1,HBB)Tow alleles Show Phenotypic Similarity to Human Syndrome: Beta Thalassemia Minor (J:148521)

References
Original:  J:134980 Wu LC, et al., Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood. 2006 Aug 15;108(4):1183-8
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory