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Bard1tm2Thl
Targeted Allele Detail
Nomenclature
Symbol: Bard1tm2Thl
Name: BRCA1 associated RING domain 1; targeted mutation 2, Thomas Ludwig
MGI ID: MGI:3790742
Synonyms: Bard1flex1
Gene: Bard1  Location: Chr1:71027498-71103146 bp, - strand  Genetic Position: Chr1, 35.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134977
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo cassette with a 5' neo cassette was inserted upstream of exon 1 and an additional neo cassette was inserted downstream of exon 1. (J:134977)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bard1 Mutation:  33 strains or lines available
References
Original:  J:134977 Shakya R, et al., The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory