Lin7c^tm2Dsb
Targeted Allele Detail

Summary

• Symbol: Lin7c^tm2Dsb
• Name: lin-7 homolog C, crumbs cell polarity complex component; targeted mutation 2, David S Bredt
• MGI ID: MGI:3790689
• Synonyms: MALS-3^flox
• Gene: Lin7c Location: Chr2:109721205-109731348 bp, + strand Genetic Position: Chr2, 56.65 cM
• Alliance: Lin7c^tm2Dsb page

Lin7c^tm2Dsb/Lin7c^tm2Dsb Tg(Pax3-cre)1Joe kidney exhibits increased apoptosis

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134806
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5 and an additional loxP site was inserted upstream of exon 4. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 4 and 5 floxed. (J:134806)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lin7c Mutation: 17 strains or lines available

References

• Original: J:134806 Olsen O, et al., Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. J Cell Biol. 2007 Oct 8;179(1):151-64
• All: 1 reference(s)