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Abcc2tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Abcc2tm1Dgen
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2; targeted mutation 1, Deltagen
MGI ID: MGI:3790671
Synonyms: Abcc2-, Mrp2-
Gene: Abcc2  Location: Chr19:43782308-43838332 bp, + strand  Genetic Position: Chr19, 36.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134950
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsNucleotides 1886 to 1897 were replaced with a lacZ-neo cassette. The absence of protein product was confirmed by western blot analysis on liver extracts. This is a null allele and a reporter allele. (J:134950)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc2 Mutation:  8 strains or lines available
References
Original:  J:134950 Chu XY, et al., Characterization of mice lacking the multidrug resistance protein MRP2 (ABCC2). J Pharmacol Exp Ther. 2006 May;317(2):579-89
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory