In(10)17Rk
Chemically induced Allele Detail

Summary

• Symbol: In(10)17Rk
• Name: inversion, Chr 10, Roderick 17
• MGI ID: MGI:3790439
• Synonyms: Hmga2^pg-J, In17Rk, pygmy Jackson
• Gene: In(10)17Rk Location: unknown Genetic Position: Chr10, Syntenic

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Inversion
• In(10)17Rk involves 1780 genes/genome features (Gm10271, B930046M08Rik, 1700026H06Rik ...) View all
• Mutation details: This triethylene melamine-induced inversion of approximately 60 cM causes a homozygous pygmy phenotype, it is allelic by complementation test with Hmga2^pg, the distal breakpoint is in intron 3 of Hmga2, and the proximal breakpoint is in intron 2 of Txlnb. A 3.7 kb fusion transcript of Hmga2 exons 4 and 5 and Txlnb exons 1 and 2 is produced. No other Txlnb transcript was found by northern blot of homozygous heart or femur. (J:28571, J:43743, J:74548)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any In(10)17Rk Mutation: 1 strain or line available

References

• Original: J:23389 Roderick TH, Using inversions to detect and study recessive lethals and detrimentals in mice, in Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. 1983:135-67.
• All: 5 reference(s)